Insulin-like Growth Factor 1 (IGF-1), LC/MS

Cleveland HeartLab I, Test

NEW YORK DOH APPROVED: YES

CPT Code: 84305
Order Code: 16293
Synonyms: IGF1, Somatomedin-C, Insulin Like Growth Factor
ABN Requirement:
No
Specimen: Serum
Volume:  0.5 mL
Minimum Volume:  0.3 mL
Container: Gel-barrier tube (SST)

Collection:

  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions included with the provided shipping box.
Special Instructions: Collect blood in a red-top or SST vacutainer. For red-top vacutainers, allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.
Stability:

Ambient (15-25°C): 48 hours
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
60 days

Causes for Rejection: Moderate hemolysis

Methodology: Liquid Chromatography/Mass Spectrometry (LC/MS)

Turn Around Time:  3-6 days

Reference Range(s):

Pediatric Male (ng/mL) Female (ng/mL)
<1 year 14-142 17-185
1-1.9 years 12-134 15-175
2-2.9 years 12-135 16-179
3-3.9 years 30-155 38-214
4-4.9 years 28-181 34-238
5-5.9 years 31-214 37-272
6-6.9 years 38-253 45-316
7-7.9 years 48-298 58-367
8-8.9 years 62-347 76-424
9-9.9 years 80-398 99-483
10-10.9 years 100-449 125-541
11-11.9 years 123-497 152-593
12-12.9 years 146-541 178-636
13-13.9 years 168-576 200-664
14-14.9 years 187-599 214-673
15-15.9 years 201-609 218-659
16-16.9 years 209-602 208-619
17-17.9 years 207-576 185-551

 

Adult ng/mL
18-19.9 years 108-548
20-24.9 years 83-456
25-29.9 years 63-373
30-39.9 years 53-331
40-49.9 years 52-328
50-59.9 years 50-317
60-69.9 years 41-279
70-79.9 years 34-245
>80 years 34-246
Z-Scores -2.0 – +2.0

Clinical Significance: Insulin-like Growth Factor 1 (IGF-1 or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.

Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.